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Human Molecular Genetics Advance Access published online on August 5, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg261
© 2003 by Oxford University Press
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©2003 Oxford University Press

Article

Genomic Microarrays in Human Genetic Disease and Cancer

Donna G. Albertson 1* and Daniel Pinkel 2

1 Cancer Research Institute, University of California San Francisco, Box 0808 , San Francisco, CA 94143-0808, USA; Department of Laboratory Medicine, University of California San Francisco, San Francisco CA 94143-0808
2 Department of Laboratory Medicine, University of California San Francisco, San Francisco CA 94143-0808

* To whom correspondence should be addressed. E-mail: albertson{at}cc.ucsf.edu.


  Abstract

Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of solid tumors and are found in association with developmental abnormalities and/or mental retardation. Comparative genomic hybridization (CGH) can be used to detect and map these changes. Recent improvements in the resolution and sensitivity of CGH have been possible through implementation of microarray-based CGH (array CGH). Here we discuss the performance characteristics of different array platforms and review some of the recent applications of array CGH in cancer and medical genetics.


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