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Human Molecular Genetics Advance Access published online on August 12, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg271
© 2003 by Oxford University Press
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©2003 Oxford University Press

Article

FLY MODELS OF HUNTINGTON'S DISEASE

J. Lawrence Marsh 1*, Judit Pallos 1, and Leslie M. Thompson 2

1 Department of Developmental and Cell Biology, 4244 McGaugh Hall, University of California, Irvine, CA 92697-2300, USA
2 Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, CA 92697-4260, USA

* To whom correspondence should be addressed. E-mail: jlmarsh{at}uci.edu.


  Abstract

Can Drosophila models be engineered that accurately reflect Huntington's disease [HD] and other neurological diseases and can they contribute to the search for treatments and cures? A number of publications seem to provide a resounding yes to that question. Here we seek to review some of the salient features of these models.

Key Words: Drosophila, polyglutamine, Huntington's disease, neurodegeneration


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