Skip Navigation



Human Molecular Genetics Advance Access published online on August 27, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg290
© 2003 by Oxford University Press
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
12/20/2577    most recent
ddg290v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Traherne, J. A
Right arrow Articles by Cookson, W. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Traherne, J. A
Right arrow Articles by Cookson, W. O.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

©2003 Oxford University Press

Article

LD mapping of maternally and non-maternally derived alleles and atopy in Fc{varepsilon}RI-{beta}

James A Traherne 1, Michael R Hill 1, Pirro Hysi 1, Mauro D'Amato 1, John Broxholme 1, Richard Mott 1, Miriam F Moffatt 1, and William OCM Cookson 2*

1 The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN
2 The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, United Kingdom

* To whom correspondence should be addressed. E-mail: wocc{at}well.ox.ac.uk.


  Abstract

Polymorphisms in the {beta} chain of the high affinity receptor for IgE (Fc{varepsilon}RI-{beta}, MS4A2) are consistently associated with traits underlying asthma and atopy (Immunoglobulin E mediated allergy). However, the causal variants and haplotypes underlying disease have not yet been identified. Maternal effects, with association confined to maternally derived alleles have been shown in some studies but not in others. We have therefore extended the known sequence and systematically detected polymorphisms across an 18.1 Kb genomic region that includes Fc{varepsilon}RI-{beta}. Association testing in two panels of subjects showed the presence of single nucleotide polymorphisms (SNPs) affecting prick skin tests and specific IgE responses in several clusters. Stepwise analyses indicated that the clusters represent independent effects. Interferon regulatory factor 2 (IRF-2) sites were altered by significantly associated SNPs in two regions. Strong association to maternally derived alleles was seen in one panel of subjects and not in the other. Maternal and non-maternally derived associations tended to share the same SNP clusters, but associations were stronger in the presence of maternal effects. Two regions of increased CpG concentration were identified in Fc{varepsilon}RI-{beta}. One of these approximated a SNP cluster that showed strong association and maternal effects, providing a potential substrate for epigenetic effects.

Key Words: Fc{varepsilon}RI-{beta}, polymorphism, atopy, linkage disequilibrium, maternal effects


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
R. L. Miller and S.-m. Ho
Environmental Epigenetics and Asthma: Current Concepts and Call for Studies
Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 567 - 573.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Nishiyama, Y. Akizawa, M. Nishiyama, T. Tokura, H. Kawada, K. Mitsuishi, M. Hasegawa, T. Ito, N. Nakano, A. Okamoto, et al.
Polymorphisms in the Fc{epsilon}RI{beta} Promoter Region Affecting Transcription Activity: A Possible Promoter-Dependent Mechanism for Association between Fc{epsilon}RI{beta} and Atopy
J. Immunol., November 15, 2004; 173(10): 6458 - 6464.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.