Skip Navigation



Human Molecular Genetics Advance Access published online on September 23, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg317
© 2003 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
12/22/3025    most recent
ddg317v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Amadou, C.
Right arrow Articles by Lindahl, K. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amadou, C.
Right arrow Articles by Lindahl, K. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

©2003 Oxford University Press

Article

Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex

Claire Amadou 1, Ruth M. Younger 2, Sarah Sims 3, Lucy H. Matthews 3, Jane Rogers 3, Attila Kumánovics 4, Andreas Ziegler 5, Stephan Beck 3, and Kirsten Fischer Lindahl 4*

1 Howard Hughes Medical Institute and Center for Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9050, USA; 10 Avenue du Mont Frouzy, F-31810 Venerque, France
2 Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1SA, UK; Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
3 Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1SA, UK
4 Howard Hughes Medical Institute and Center for Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9050, USA
5 Institut für Immungenetik, Charité, Humboldt-Universität zu Berlin, D-14050 Berlin, Germany

* To whom correspondence should be addressed. E-mail: KFL{at}chop.swmed.edu.


  Abstract

We report the 897-kb sequence of a cluster of olfactory receptor (OR) genes located at the distal end of the major histocompatibility complex (MHC) class I region on mouse chromosome 17 of strain 129/SvJ (H2bc). With additional information from the mouse genome draft sequence, we identified 59 OR loci ({approx}20% pseudogenes) in contrast to only 25 OR loci ({approx}50% pseudogenes) in the corresponding centromeric OR cluster that is part of the "extended MHC class I region" on human chromosome 6. Comparative analysis leads to three major observations: (i) Most of the OR subfamilies have evolved independently in the two species, expanding more in the mouse, and resulting in co-orthologs: subfamilies of highly similar paralogs that keep orthologous relationships with their human counterparts. (ii) Three of the mouse OR subfamilies have no orthologs in humans. (iii) MHC class I loci are interspersed in the OR cluster in mouse but not in human, and were subjected to co-duplication with OR genes. Screening of our sequence against the available sequences of other strains/haplotypes revealed that most of the OR loci are polymorphic and that the number of OR loci may vary among strains/haplotypes. Our findings that MHC-linked OR loci share duplication with MHC class I loci, have duplicated extensively and are polymorphic revives questions about potential reciprocal influences acting on the dynamics and evolution of the H2 region and the H2-linked OR loci.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Genome ResHome page
A. M. Snijders, N. J. Nowak, B. Huey, J. Fridlyand, S. Law, J. Conroy, T. Tokuyasu, K. Demir, R. Chiu, J.-H. Mao, et al.
Mapping segmental and sequence variations among laboratory mice using BAC array CGH
Genome Res., February 1, 2005; 15(2): 302 - 311.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.