Skip Navigation



Human Molecular Genetics Advance Access published online on September 23, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg318
© 2003 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
12/22/2923    most recent
ddg318v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Memisoglu, A.
Right arrow Articles by Hunter, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Memisoglu, A.
Right arrow Articles by Hunter, D. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

©2003 Oxford University Press

Article

Interaction between a peroxisome proliferator-activated receptor {gamma} gene polymorphism and dietary fat intake in relation to body mass

Asli Memisoglu 1*, Frank B. Hu 2, Susan E. Hankinson 3, JoAnn E. Manson 4, Immaculata De Vivo 5, Walter C. Willett 6, and David J. Hunter 7

1 Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Bldg II Rm 109, Boston, MA 02115
2 Department of Nutrition, Harvard School of Public Health, Boston, MA
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA
4 Department of Epidemiology, Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA; Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA
5 Department of Epidemiology, Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA; Harvard Center for Cancer Prevention, Boston, MA
6 Department of Epidemiology, Harvard School of Public Health, Boston, MA; Department of Nutrition, Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA
7 Department of Epidemiology, Harvard School of Public Health, Boston, MA; Department of Nutrition, Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA; Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

* To whom correspondence should be addressed. E-mail: amemisog{at}hsph.harvard.edu.


  Abstract

The peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) is a critical regulator of adipogenesis. PPAR{gamma} +/- mice are resistant to high-fat diet-induced obesity and thus PPAR{gamma} may mediate physiological responses to dietary fat in other mammals. The aim of this study was to determine whether the human PPAR{gamma} proline to alanine substitution polymorphism (Pro12Ala) modifies the association between dietary fat and adiposity and plasma lipids. Subjects (n=2141) were controls selected for three case-control studies nested within the Nurses' Health Study, a large ongoing prospective cohort study. Associations between intake of total fat, fat subtypes and BMI were different in PPAR{gamma} 12Ala variant allele-carriers compared with non-carriers. Among homozygous wildtype Pro/Pro individuals, those in the highest quintile of total fat intake had significantly higher mean BMI compared to those in the lowest quintile (27.3 versus 25.4 kg/m2, respectively; p-trend <0.0001) whereas among 12Ala variant allele-carriers there was no significant trend observed between dietary fat intake and BMI (p-trend = 0.99; p-interaction = 0.003). In contrast, intake of monounsaturated was not associated with BMI among homozygous wildtype women but was inversely associated with BMI among 12Ala variant allele-carriers (mean in lowest quintile = 27.6 versus mean in highest quintile = 25.5 kg/m2; p-trend = 0.006; p-interaction = 0.003). The relationship between dietary fat intake and plasma lipid concentrations also differed according to PPAR{gamma} genotype. These data suggest that PPAR{gamma} genotype is an important factor in physiological responses to dietary fat in humans.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
D. O. Mook-Kanamori, E. A.P. Steegers, A. G. Uitterlinden, H. A. Moll, C. M. van Duijn, A. Hofman, and V. W.V. Jaddoe
Breast-Feeding Modifies the Association of PPAR{gamma}2 Polymorphism Pro12Ala With Growth in Early Life: The Generation R Study
Diabetes, April 1, 2009; 58(4): 992 - 998.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. E Cecil, C. N. Palmer, B. Fischer, P. Watt, D. J Wallis, I. Murrie, and M. M Hetherington
Variants of the peroxisome proliferator-activated receptor {gamma}- and {beta}-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children
Am. J. Clinical Nutrition, July 1, 2007; 86(1): 167 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
O. Vaccaro, E. Lapice, A. Monticelli, M. Giacchetti, I. Castaldo, R. Galasso, M. Pinelli, G. Donnarumma, A. A. Rivellese, S. Cocozza, et al.
Pro12Ala Polymorphism of the PPAR{gamma}2 Locus Modulates the Relationship Between Energy Intake and Body Weight in Type 2 Diabetic Patients
Diabetes Care, May 1, 2007; 30(5): 1156 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. D. Yee, N. Williams, P. Wen, D. C. Young, J. Lester, M. V. Johnson, W. B. Farrar, M. J. Walker, S. P. Povoski, S. Suster, et al.
Pilot Study of Rosiglitazone Therapy in Women with Breast Cancer: Effects of Short-term Therapy on Tumor Tissue and Serum Markers
Clin. Cancer Res., January 1, 2007; 13(1): 246 - 252.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
F. Soriguer, S. Morcillo, F. Cardona, G. Rojo-Martinez, M. de la Cruz Almaraz, M. de la Soledad Ruiz de Adana, G. Olveira, F. Tinahones, and I. Esteva
Pro12Ala Polymorphism of the PPARG2 Gene Is Associated with Type 2 Diabetes Mellitus and Peripheral Insulin Sensitivity in a Population with a High Intake of Oleic Acid
J. Nutr., September 1, 2006; 136(9): 2325 - 2330.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Pischon, J. K. Pai, J. E. Manson, F. B. Hu, K. M. Rexrode, D. Hunter, and E. B. Rimm
Peroxisome Proliferator-Activated Receptor-{gamma}2 P12A Polymorphism and Risk of Coronary Heart Disease in US Men and Women
Arterioscler Thromb Vasc Biol, August 1, 2005; 25(8): 1654 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
V. Paracchini, P. Pedotti, and E. Taioli
Genetics of Leptin and Obesity: A HuGE Review
Am. J. Epidemiol., July 15, 2005; 162(2): 101 - 114.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Vanttinen, P. Nuutila, J. Pihlajamaki, K. Hallsten, K. A. Virtanen, R. Lautamaki, P. Peltoniemi, J. Kemppainen, T. Takala, A. P. M. Viljanen, et al.
The Effect of the Ala12 Allele of the Peroxisome Proliferator-Activated Receptor-{gamma}2 Gene on Skeletal Muscle Glucose Uptake Depends on Obesity: A Positron Emission Tomography Study
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4249 - 4254.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. A. Murtaugh, K.-n. Ma, B. J. Caan, C. Sweeney, R. Wolff, W. S. Samowitz, J. D. Potter, and M. L. Slattery
Interactions of Peroxisome Proliferator-Activated Receptor {gamma} and Diet in Etiology of Colorectal Cancer
Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1224 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S.-M. Brand-Herrmann, T. Kuznetsova, A. Wiechert, K. Stolarz, V. Tikhonoff, K. Schmidt-Petersen, R. Telgmann, E. Casiglia, J.-G. Wang, L. Thijs, et al.
Alcohol intake modulates the genetic association between HDL cholesterol and the PPAR{gamma}2 Pro12Ala polymorphism
J. Lipid Res., May 1, 2005; 46(5): 913 - 919.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
R. L. Prentice, W. C. Willett, P. Greenwald, D. Alberts, L. Bernstein, N. F. Boyd, T. Byers, S. K. Clinton, G. Fraser, L. Freedman, et al.
Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations
J Natl Cancer Inst, September 1, 2004; 96(17): 1276 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
W. C. Willett
Reduced-Carbohydrate Diets: No Roll in Weight Management?
Ann Intern Med, May 18, 2004; 140(10): 836 - 837.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.