Skip Navigation



Human Molecular Genetics Advance Access published online on September 23, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg325
© 2003 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
12/22/2931    most recent
ddg325v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cui, C.-Y.
Right arrow Articles by Schlessinger, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cui, C.-Y.
Right arrow Articles by Schlessinger, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

©2003 Oxford University Press

Article

Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles

Chang-Yi Cui 1, Meredith Durmowicz 1, Chris Ottolenghi 1, Tsuyoshi Hashimoto 1, Bradley Griggs 2, Anand K Srivastava 2, and David Schlessinger 3*

1 Laboratory of Genetics, NIH/National Institute on Aging, Baltimore, MD 21224, USA
2 J.C. Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, SC 29646, USA
3 Laboratory of Genetics, NIH/National Institute on Aging, 333 Cassell Dr., Suite 3000, Baltimore, MD 21224, USA

* To whom correspondence should be addressed. E-mail: SchlessingerD{at}grc.nia.nih.gov.


  Abstract

EDA splice isoforms EDA-A1 and EDA-A2 belong to the TNF ligand family and regulate skin appendage formation by activating NF-kB- and JNK- promoted transcription. To analyze their action further, we conditionally expressed the isoforms as tetracycline ("Tet")-regulated transgenes in Tabby (EDA-negative) and wild-type mice. Expression of only the mEDA-A1 transgene had two types of effects during embryogenesis: 1) determinative effects on sweat glands and hair follicles. In Tabby mice, one type of hair follicle ("guard hair") was restored, whereas a second type, the dominant undercoat hair follicle ("zigzag") was not; furthermore, the transgene sharply suppressed zigzag hair formation in wild-type mice, with the overall numbers of back hair follicles remaining the same; and 2) trophic effects on sebaceous and Meibomian glands. Marked hyperplasia resulted from expansion of the sebocyte-producing zone in sebaceous glands, with particularly high expression of the transgene and the replication marker PCNA, and correspondingly high production of sebum. The phenotypic effects of mEDA-A1 on sebaceous glands, but not on hair follicles, were reversed when the gene was repressed in adult animals. The results thus reveal both initiating and trophic isoform-specific effects of the EDA gene, and suggest a possible balance of isoform interactions in skin appendage formation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
M. Kunisada, C.-Y. Cui, Y. Piao, M. S.H. Ko, and D. Schlessinger
Requirement for Shh and Fox family genes at different stages in sweat gland development
Hum. Mol. Genet., May 15, 2009; 18(10): 1769 - 1778.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C.-Y. Cui, M. Kunisada, D. Esibizione, S. I. Grivennikov, Y. Piao, S. A. Nedospasov, and D. Schlessinger
Lymphotoxin-{beta} regulates periderm differentiation during embryonic skin development
Hum. Mol. Genet., November 1, 2007; 16(21): 2583 - 2590.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Y. Fessing, T. Y. Sharova, A. A. Sharov, R. Atoyan, and V. A. Botchkarev
Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)
Am. J. Pathol., December 1, 2006; 169(6): 2075 - 2084.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C.-Y. Cui, T. Hashimoto, S. I. Grivennikov, Y. Piao, S. A. Nedospasov, and D. Schlessinger
Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation
PNAS, June 13, 2006; 103(24): 9142 - 9147.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Schmidt-Ullrich, D. J. Tobin, D. Lenhard, P. Schneider, R. Paus, and C. Scheidereit
NF-{kappa}B transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth
Development, March 15, 2006; 133(6): 1045 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C.-Y. Cui, J. A. Smith, D. Schlessinger, and C.-C. Chan
X-Linked Anhidrotic Ectodermal Dysplasia Disruption Yields a Mouse Model for Ocular Surface Disease and Resultant Blindness
Am. J. Pathol., July 1, 2005; 167(1): 89 - 95.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Schlake
FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5
Development, July 1, 2005; 132(13): 2981 - 2990.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
U. Guha, L. Mecklenburg, P. Cowin, L. Kan, W. M. O'Guin, D. D'Vizio, R. G. Pestell, R. Paus, and J. A. Kessler
Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling
Am. J. Pathol., September 1, 2004; 165(3): 729 - 740.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.