Human Molecular Genetics Advance Access published online on November 25, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddh021
© 2003 by Oxford University Press
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Rheumatology Section, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, UK
* To whom correspondence should be addressed. E-mail: t.vyse{at}imperial.ac.uk.
Relative deficiency of pentraxin proteins is implicated in the pathogenesis of systemic lupus erythematosus. The C-reactive protein (CRP) response is defective in patients with acute flares of disease, and mice with targeted deletions of the serum amyloid P component gene (Sap) develop a lupus-like illness. In humans, the genes for CRP (CRP) and SAP (APCS) map to 1q23.2 within an interval linked with SLE. We have investigated the candidate genes CRP and APCS in two cohorts totalling 586 UK simplex SLE families. The inheritance of an intronic dinucleotide repeat and seven single nucleotide polymorphisms in the CRP and APCS genes were examined by application of family-based tests of association and linkage. Basal levels of CRP were influenced independently by two polymorphisms at the CRP locus, CRP 2 and CRP 4. Furthermore, the latter polymorphism was linked/associated with SLE and antinuclear autoantibody production. Thus, the polymorphism associated with reduced basal CRP was also associated with the development of SLE. These data support the hypothesis that defective disposal of potentially immunogenic material is a contributory factor in lupus pathogenesis. The identification of polymorphisms that determine basal CRP levels have implications in ischaemic heart disease, where CRP level is an important predictor of risk.
Article
Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus
2 Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, St Mary's Campus, Norfolk Place, London W2 1PG, UK
3 Department of Pathology, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, UK
4 Clinical Immunology Unit, Queen's Medical Centre, Nottingham NG7 2UH, UK
5 The Middlesex Hospital, University College London, Arthur Stanley House, Tottenham Street, London W1T 4NJ, UK
6 Rheumatology Section, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, UK; The Wellcome Trust, Euston Road, London NW1 2BE
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Bertoli, L. Vila, G. Alarcon, G McGwin, J. Edberg, M Petri, R Ramsey-Goldman, J. Reveille, R. Kimberly, and for the PROFILE Study Group Factors Associated with Arterial Vascular Events in PROFILE: A Multiethnic Lupus Cohort Lupus, October 1, 2009; 18(11): 958 - 965. [Abstract] [PDF]
|
|
|
|
 |
|
 H.-A. KIM, H.-Y. CHUN, S.-H. KIM, H.-S. PARK, and C.-H. SUH C-Reactive Protein Gene Polymorphisms in Disease Susceptibility and Clinical Manifestations of Korean Systemic Lupus Erythematosus J Rheumatol, October 1, 2009; 36(10): 2238 - 2243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pertovaara, M. Kahonen, M. Juonala, T. Laitinen, L. Taittonen, T. Lehtimaki, J. S. A. Viikari, O. T. Raitakari, and M. Hurme Autoimmunity and atherosclerosis: the presence of antinuclear antibodies is associated with decreased carotid elasticity in young women. The Cardiovascular Risk in Young Finns Study Rheumatology, September 24, 2009; (2009) kep288v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. HELLQUIST, T. M. JARVINEN, S. KOSKENMIES, M. ZUCCHELLI, C. ORSMARK-PIETRAS, L. BERGLIND, J. PANELIUS, T. HASAN, H. JULKUNEN, M. D'AMATO, et al. Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus Erythematosus J Rheumatol, August 1, 2009; 36(8): 1631 - 1638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. P Almeida, P. E Norman, R. Allcock, F. v. Bockxmeer, G. J Hankey, K. Jamrozik, and L. Flicker Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study Int. J. Epidemiol., August 1, 2009; 38(4): 1049 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. PALOMINO-MORALES, T. R. VAZQUEZ-RODRIGUEZ, J. A. MIRANDA-FILLOY, J. MARTIN, and M. A. GONZALEZ-GAY C-Reactive Protein Gene Polymorphisms in Biopsy-proven Giant Cell Arteritis from Northwestern Spain J Rheumatol, February 1, 2009; 36(2): 341 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Schumacher, J. Cockcroft, N. J. Timpson, C. M. McEniery, J. Gallacher, A. Rumley, G. Lowe, G. D. Smith, I. B. Wilkinson, and Y. Ben-Shlomo Association Between C-Reactive Protein Genotype, Circulating Levels, and Aortic Pulse Wave Velocity Hypertension, February 1, 2009; 53(2): 150 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. B. Grammer, W. Marz, W. Renner, B. O. Bohm, and M. M. Hoffmann C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: the LURIC study Eur. Heart J., January 2, 2009; 30(2): 170 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sunyer, R. Pistelli, E. Plana, M. Andreani, F. Baldari, M. Kolz, W. Koenig, J. Pekkanen, A. Peters, and F. Forastiere Systemic inflammation, genetic susceptibility and lung function Eur. Respir. J., July 1, 2008; 32(1): 92 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kolz, W. Koenig, M. Muller, M. Andreani, S. Greven, T. Illig, N. Khuseyinova, D. Panagiotakos, G. Pershagen, V. Salomaa, et al. DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study Eur. Heart J., May 2, 2008; 29(10): 1250 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Edberg, J. Wu, C. D. Langefeld, E. E. Brown, M. C. Marion, G. McGwin Jr, M. Petri, R. Ramsey-Goldman, J. D. Reveille, S. G. Frank, et al. Genetic variation in the CRP promoter: association with systemic lupus erythematosus Hum. Mol. Genet., April 15, 2008; 17(8): 1147 - 1155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gallicchio, H. Chang, D. K. Christo, L. Thuita, H.-Y. Huang, P. Strickland, I. Ruczinski, S. C. Hoffman, and K. J. Helzlsouer Single Nucleotide Polymorphisms in Inflammation-related Genes and Mortality in a Community-based Cohort in Washington County, Maryland Am. J. Epidemiol., April 1, 2008; 167(7): 807 - 813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Gorman, A. I. Russell, Z. Zhang, D. Cunninghame Graham, A. P. Cope, and T. J. Vyse Polymorphisms in the CD3Z Gene Influence TCR{zeta} Expression in Systemic Lupus Erythematosus Patients and Healthy Controls J. Immunol., January 15, 2008; 180(2): 1060 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Hage and A. J. Szalai C-Reactive Protein Gene Polymorphisms, C-Reactive Protein Blood Levels, and Cardiovascular Disease Risk J. Am. Coll. Cardiol., September 18, 2007; 50(12): 1115 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jonsen, I. Gunnarsson, B. Gullstrand, E. Svenungsson, A. A. Bengtsson, O. Nived, I. E. Lundberg, L. Truedsson, and G. Sturfelt Association between SLE nephritis and polymorphic variants of the CRP and Fc{gamma}RIIIa genes Rheumatology, September 1, 2007; 46(9): 1417 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Mathew, M. V. Podgoreanu, H. P. Grocott, W. D. White, R. W. Morris, M. Stafford-Smith, G. B. Mackensen, C. S. Rinder, J. A. Blumenthal, D. A. Schwinn, et al. Genetic Variants in P-Selectin and C-Reactive Protein Influence Susceptibility to Cognitive Decline After Cardiac Surgery J. Am. Coll. Cardiol., May 15, 2007; 49(19): 1934 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hellquist, M. Zucchelli, K. Kivinen, U. Saarialho-Kere, S. Koskenmies, E. Widen, H. Julkunen, A. Wong, M.-L. Karjalainen-Lindsberg, T. Skoog, et al. The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus J. Med. Genet., May 1, 2007; 44(5): 314 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dehghan, I. Kardys, M. P.M. de Maat, A. G. Uitterlinden, E. J.G. Sijbrands, A. H. Bootsma, T. Stijnen, A. Hofman, M. T. Schram, and J. C.M. Witteman Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes Diabetes, March 1, 2007; 56(3): 872 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wang, S. C. Hunt, Q. Xu, Y. E. Chen, M. A. Province, J. H. Eckfeldt, J. S. Pankow, and Q. Song Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2752 - H2757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Rigby, M. M. A. Fernando, and T. J. Vyse Mice, humans and haplotypes--the hunt for disease genes in SLE Rheumatology, September 1, 2006; 45(9): 1062 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P Casas, T. Shah, J. Cooper, E. Hawe, A. D McMahon, D. Gaffney, C. J Packard, D. S O'Reilly, I. Juhan-Vague, J. S Yudkin, et al. Insight into the nature of the CRP-coronary event association using Mendelian randomization Int. J. Epidemiol., August 1, 2006; 35(4): 922 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kardys, M. P.M. de Maat, A. G. Uitterlinden, A. Hofman, and J. C.M. Witteman C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study Eur. Heart J., June 1, 2006; 27(11): 1331 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Huber, S. Gay, O. Distler, and D. S. Pisetsky The effect of UVB on lupus skin: new light on the role of apoptosis in the pathogenesis of autoimmunity Rheumatology, May 1, 2006; 45(5): 500 - 501. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kathiresan, M. G. Larson, R. S. Vasan, C.-Y. Guo, P. Gona, J. F. Keaney Jr, P. W.F. Wilson, C. Newton-Cheh, S. L. Musone, A. L. Camargo, et al. Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level Circulation, March 21, 2006; 113(11): 1415 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Vermeire, G Van Assche, and P Rutgeerts Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut, March 1, 2006; 55(3): 426 - 431. [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Schleimer Innate Immune Responses and Chronic Obstructive Pulmonary Disease: "Terminator" or "Terminator 2"? Proceedings of the ATS, November 1, 2005; 2(4): 342 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Szalai, G. S. Alarcon, J. Calvo-Alen, S. M. A. Toloza, M. A. McCrory, J. C. Edberg, G. McGwin Jr, H. M. Bastian, B. J. Fessler, L. M. Vila, et al. Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events Rheumatology, July 1, 2005; 44(7): 864 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Ozen and A Bakkaloglu C reactive protein: protecting from lupus in familial Mediterranean fever Ann Rheum Dis, May 1, 2005; 64(5): 786 - 787. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Black, I. Kushner, and D. Samols C-reactive Protein J. Biol. Chem., November 19, 2004; 279(47): 48487 - 48490. [Abstract] [Full Text] [PDF]
|
|