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Human Molecular Genetics Advance Access published online on August 26, 2005
Human Molecular Genetics, doi:10.1093/hmg/ddi308
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© The Author 2005. Published by Oxford University Press. All rights reserved
Received August 2, 2005
Accepted August 6, 2005

Article

Molecular pathogenesis of Parkinson's disease

Sonia Gandhi 1 and Nicholas W. Wood 1*

1 Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London

* To whom correspondence should be addressed.
Nicholas W. Wood, E-mail: n.wood{at}ion.ucl.ac.uk


  Abstract

Parkinson's disease is a common and incurable neurodegenerative disease, affecting 1% of the population over the age of 65. Despite a well described clinical and pathological phenotype the molecular mechanisms which lead to neurodegeneration remain elusive. However there is a wealth of evidence from both toxin based models and genetic based models that suggest a major etiologic role for mitochondrial dysfunction, protein aggregation, the ubiquitin proteasome system, and kinase signalling pathways in the pathogenesis of Parkinson's disease. Ultimately an understanding of the molecular events which precipitate neurodegeneration in idiopathic Parkinson's disease will enable the development of targeted and effective therapeutic strategies. We review the latest evidence for the proposed molecular processes and discuss their relevance to the pathogenesis of sporadic Parkinson's disease.


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