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Human Molecular Genetics Advance Access published online on January 13, 2006
Human Molecular Genetics, doi:10.1093/hmg/ddi481
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© The Author 2006. Published by Oxford University Press. All rights reserved
Received November 11, 2005
Revised January 8, 2006
Accepted January 8, 2006

Article

Genetic Variation in DTNBP1 Influences General Cognitive Ability

Katherine E. Burdick 1 *, Todd Lencz 2, Birgit Funke 3, Christine T. Finn 3, Philip R. Szeszko 2, John M. Kane 2, Raju Kucherlapati 3, and Anil K. Malhotra 2

1 Department of Psychiatry Research, The Zucker Hillside Hospital, North-Shore-Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY. Albert Einstein College of Medicine, 11004
2 Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY. Albert Einstein College of Medicine
3 Harvard Partners Center for Genetics and Genomics, Boston, MA

* To whom correspondence should be addressed.
Katherine E. Burdick, E-mail: kburdick{at}lij.edu


  Abstract

Human intelligence is a trait that is known to be significantly influenced by genetic factors and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in 2 independent cohorts, including 213 patients with schizophrenia or schizoaffective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.


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