Skip Navigation



Human Molecular Genetics Advance Access published online on January 18, 2006
Human Molecular Genetics, doi:10.1093/hmg/ddi485
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
15/5/717    most recent
ddi485v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Choo, J. H.
Right arrow Articles by Kim, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Choo, J. H.
Right arrow Articles by Kim, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved
Received November 22, 2005
Revised January 12, 2006
Accepted January 12, 2006

Article

Allele-specific deposition of macroH2A1 in Imprinting Control Regions

Jung Ha Choo 1, Jeong Do Kim 2, Jae Hoon Chung 3, Lisa Stubbs 4, and Joomyeong Kim 2 *

1 Department of Biological Sciences, Center for BioModular Multi-scale Systems, Louisiana State University, Baton Rouge, LA 70803; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea
2 Department of Biological Sciences, Center for BioModular Multi-scale Systems, Louisiana State University, Baton Rouge, LA 70803
3 Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea
4 Genome Biology Division, Lawrence Livermore National Laboratory, Livermore, CA 94551

* To whom correspondence should be addressed.
Joomyeong Kim, E-mail: jkim{at}lsu.edu


  Abstract

In the current study, we analyzed the deposition patterns of macroH2A1 at a number of different genomic loci located in X chromosome and autosomes. MacroH2A1 is preferentially deposited at methylated CpG-rich regions located close to promoters. The macroH2A1 deposition patterns at the methylated CpG islands of several imprinted domains, including the Imprinting Control Regions (ICRs) of Xist, Peg3, H19/Igf2, Gtl2/Dlk1, and Gnas domains, show consistent allele-specificity towards inactive, methylated alleles. The macroH2A1 deposition levels at the ICRs and other Differentially Methylated Regions (DMRs) of these domains are also either higher or comparable to those observed at the inactive X chromosome of female mammals. Overall, our results indicate that besides DNA methylation macroH2A1 is another epigenetic component in the chromatin of ICRs displaying differential association with two parental alleles.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Bernstein, T. L. Muratore-Schroeder, R. L. Diaz, J. C. Chow, L. N. Changolkar, J. Shabanowitz, E. Heard, J. R. Pehrson, D. F. Hunt, and C. D. Allis
A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis
PNAS, February 5, 2008; 105(5): 1533 - 1538.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Han, D.-H. Lee, and P. E. Szabo
CTCF Is the Master Organizer of Domain-Wide Allele-Specific Chromatin at the H19/Igf2 Imprinted Region
Mol. Cell. Biol., February 1, 2008; 28(3): 1124 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Damelin and T. H. Bestor
Biological Functions of DNA Methyltransferase 1 Require Its Methyltransferase Activity
Mol. Cell. Biol., June 1, 2007; 27(11): 3891 - 3899.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.