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Human Molecular Genetics Advance Access published online on February 23, 2006
Human Molecular Genetics, doi:10.1093/hmg/ddl033
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© The Author 2006. Published by Oxford University Press. All rights reserved
Received January 6, 2006
Revised February 9, 2006
Accepted February 15, 2006

Article

Genetic polymorphisms of Ataxia Telangiectasia Mutated affect lung cancer risk

Jin Hee Kim 1, Heon Kim 2, Kye Young Lee 3, Kang-Hyeon Choe 4, Jeong-Seon Ryu 5, Ho Il Yoon 6, Sook Whan Sung 7, Keun-Young Yoo 1, and Yun-Chul Hong 8 *

1 Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Republic of Korea
2 Department of Preventive Medicine, College of Medicine, Chungbuk National University, 12 Kaeshin-dong Hungdok-gu Cheongju-si Chungbuk 361-763, Republic of Korea
3 Department of Internal Medicine, School of Medicine, Konkuk University, #4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea
4 Department of Internal Medicine, College of Medicine, Chungbuk National University, 12 Kaeshin-dong Hungdok-gu Cheongju-si Chungbuk 361-763, Republic of Korea
5 Department of Internal Medicine, College of Medicine, Inha University, 7-206 Shinhung-dong 3ga, Jung-gu, Incheon 400-103, Republic of Korea
6 Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Republic of Korea; Department of Internal Medicine, National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Geongi-do 463-707, Republic of Korea
7 Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Geongi-do 463-707, Republic of Korea; Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Republic of Korea
8 Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Republic of Korea; Institute of Environmental Medicine, SNUMRC, 28 Yongon-dong, Chongno-Gu, Seoul 110-799, Republic of Korea

* To whom correspondence should be addressed.
Yun-Chul Hong, E-mail: ychong1{at}snu.ac.kr


  Abstract

The Ataxia Telangiectasia Mutated (ATM) gene is known to be activated by DNA damage and involved in cell cycle arrest, apoptosis, and DNA repair. Therefore, ATM gene polymorphisms may act as important factors predicting individual susceptibility to lung cancer. In order to evaluate the role of ATM gene polymorphisms in lung cancer development, genotypes of the ATM polymorphisms, -4518A > G, IVS21-77C > T, IVS61-55T > C, and IVS62 + 60G > A, were determined in 616 lung cancer patients and 616 cancer-free controls. When the effects of selected ATM genotypes were evaluated separately, only one ATM genotype (IVS62 + 60G>A) showed an association with lung cancer risk. Subjects with the A allele at the site (IVS62 + 60G > A) have significantly higher risk of lung cancer than those with the G allele (OR, 1.6, 95% CI, 1.1-2.1). When the haplotypes of four ATM SNP sites (-4518A > G, IVS21-77C > T, IVS61-55T > C, and IVS62 + 60G > A) were studied, the ATTA haplotype showed significantly increased risk of lung cancer compared with the GCCA haplotype, the most common haplotype (OR, 7.6, 95% CI, 1.7-33.5). Furthermore, subjects with the (NN)TA haplotype showed highly significant and increased risk of lung cancer when compared with those without the (NN)TA haplotype (OR = 13.2, 95% CI, 3.1-56.1). Therefore, our results suggest that polymorphisms or haplotypes of the ATM gene play an important role in the development of lung cancer.


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