Skip Navigation



Human Molecular Genetics Advance Access published online on April 12, 2006
Human Molecular Genetics, doi:10.1093/hmg/ddl097
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
15/10/1735    most recent
ddl097v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Ciullo, M.
Right arrow Articles by Persico, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ciullo, M.
Right arrow Articles by Persico, M. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org
Received January 10, 2006
Revised March 31, 2006
Accepted March 31, 2006

Article

New Susceptibility Locus for Hypertension on Chromosome 8q by Efficient Pedigree Breaking in an Italian Isolate

Marina Ciullo 1 *, Céline Bellenguez 2, Vincenza Colonna 3, Teresa Nutile 3, Antonietta Calabria 3, Rosalinda Pacente 3, Gianluigi Iovino 4, Bruno Trimarco 4, Catherine Bourgain 2, and M. Graziella Persico 3

1 Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, Via Pietro Castellino, 111, 80131, Naples, Italy
2 UMR 535 INSERM, University of Paris XI, Villejuif. France
3 Institute of Genetics and Biophysics "A. Buzzati-Traverso", CNR Naples, Italy
4 Department of Clinical Medicine and Cardiovascular Sciences, University of Naples 'Federico II', Naples, Italy

* To whom correspondence should be addressed.
Marina Ciullo, E-mail: ciullo{at}igb.cnr.it


  Abstract

Essential hypertension (EH) affects a large proportion of the adult population in Western countries and is a major risk factor for cardiovascular diseases. EH is a multifactorial disease with a complex genetic component. To tackle the complexity of this genetic component, we have initiated a study of Campora, an isolated village in South Italy. A random sample of 389 adults were genotyped for a very dense microsatellite genome scan and phenotyped for EH. Of this sample, 173 affected individuals were all related through a 2180-member pedigree and could be integrated within a linkage analysis. The complexity of the pedigree prevented its direct use for a non parametric linkage (NPL) analysis. Therefore, the method proposed by Falchi and co-workers (1) was used for automatic pedigree-breaking. We identified a new locus for EH on chromosome 8q22-23 and detected linkage with two known loci for EH: 1q42-43 and 4p16. Simulations showed that the linkage with 8q22-23 is highly genome-wide significant, even when accounting for the breaking of the pedigree. An extension to qualitative traits of another pedigree breaking approach (2) also detected a significant linkage on 8q22-23 using a remarkably different set of sub-pedigrees and helped to refine the location of the linkage signal. This work both identifies a new locus strongly linked to hypertension and shows that the power of linkage analysis can be improved by the appropriate use of efficient pedigree breaking strategies.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
M. Falchi and C. Fuchsberger
Jenti: an efficient tool for mining complex inbred genealogies
Bioinformatics, March 1, 2008; 24(5): 724 - 726.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Ciullo, T. Nutile, C. Dalmasso, R. Sorice, C. Bellenguez, V. Colonna, M. G. Persico, and C. Bourgain
Identification and Replication of a Novel Obesity Locus on Chromosome 1q24 in Isolated Populations of Cilento
Diabetes, March 1, 2008; 57(3): 783 - 790.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.