Skip Navigation



Human Molecular Genetics Advance Access published online on August 1, 2007
Human Molecular Genetics, doi:10.1093/hmg/ddm210
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
16/21/2583    most recent
ddm210v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cui, C.-Y.
Right arrow Articles by Schlessinger, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cui, C.-Y.
Right arrow Articles by Schlessinger, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Lymphotoxin-ß regulates periderm differentiation during embryonic skin development

Chang-Yi Cui1, Makoto Kunisada1, Diana Esibizione1,2, Sergei I. Grivennikov3, Yulan Piao1, Sergei A. Nedospasov4 and David Schlessinger1,*

1 Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA 2 Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna 40126, Italy 3 Basic Research Laboratory, National Cancer Institute, P.O. Box B, Frederick, Maryland, 21702, USA 4 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia

* Corresponding author: Laboratory of Genetics, National Institute on Aging/ NIH, 333 Cassell Dr., Suite 3000, Baltimore, Maryland 21224, USA. Tel: 410-558-8337, Fax: 410-558-8331, E-mail: SchlessingerD{at}grc.nia.nih.gov

Lymphotoxin-ß (LTß) is a key regulator of immune system development, but also affects late stages in hair development. In addition, high expression of LTß at an early stage in epidermis hinted at a further function in hair follicle induction or epithelial development. We report that hair follicles were normally induced in LTß-/- skin, but the periderm detached from the epidermis earlier, accompanied by premature appearance of keratohyalin granules. Expression profiling revealed dramatic downregulation of a gene cluster encoding periderm-specific keratin associated protein 13 and 4 novel paralogs in LTß-/- skin prior to periderm detachment. Epidermal differentiation markers, including small proline-rich proteins, filaggrins and several keratins, were also affected, but transiently in LTß-/- skin at the time of abnormal periderm detachment. As expected, Tabby mice, which lack the EDA gene, the putative upstream regulator of LTß in skin, showed similar though milder periderm histopathology and alterations in gene expression. Overall, LTß shows a primary early function in periderm differentiation, with later transient effects on epidermal and hair follicle differentiation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.