Human Molecular Genetics Advance Access first published online on September 19, 2007
This version published online on October 3, 2007
Human Molecular Genetics, doi:10.1093/hmg/ddm271
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Paternal Age at Birth is an Important Determinant of Offspring Telomere Length
1 Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium 2 Department of Cardiovascular Diseases, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium 3 Department of Public Health, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
* Corresponding author: Tim De Meyer Dept. Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium Tel.: + 32 9 264 99 22 Fax: + 32 9 264 62 19 E-mail: Tim.DeMeyer{at}ugent.be
Received August 21, 2007; Revised September 14, 2007; Accepted September 14, 2007
Although evidence supports the function of telomere length (TL) as a marker for biological aging, no major determinants of TL are known besides inheritance, age and gender. Here we validate and, more importantly, assess the impact of paternal age at birth as a determinant for the offspring's peripheral blood leukocyte TL within the Asklepios study population.
Telomere restriction fragment length and paternal age information were available for 2433 volunteers (1176 men and 1257 women) aged approximately 35-55 years old. Paternal age at birth was positively associated with offspring TL (offspring age and gender adjusted, P < 10(-14)). The increase in TL was estimated at 17 base pairs for each supplemental year at birth and was not statistically different between male and female offspring. The effect size of paternal age outweighed the classical TL determinant gender by a factor two, demonstrating the large impact. Maternal age at birth was not independently associated with offspring TL.
The peculiar interaction between paternal age at birth and inheritance might explain a large part of the genetic component of TL variance on a population level. This finding also provides further proof for the theory that TL is not completely reset in the zygote. Furthermore, as paternal age is subject to demographic evolution, its association with TL might have a substantial impact on the results and comparability of TL within and between epidemiological studies. In conclusion, paternal age is an important determinant for TL, with substantial consequences for future studies.
This paper has been versioned to publish it under the Open Access copyright model.