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Human Molecular Genetics Advance Access published online on January 4, 2008
Human Molecular Genetics, doi:10.1093/hmg/ddn001
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence

Werner Koch1,2,*, Petra Hoppmann1,2, Antoinette de Waha1,2, Albert Schömig1,2 and Adnan Kastrati1,2

1 Deutsches Herzzentrum München, 80636 Munich, Germany 2 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

* To whom correspondence should be addressed at: Deutsches Herzzentrum München Lazarettstrasse 36, 80636 Munich, Germany. Tel: +49 8912182601 FAX: +49 8912183053 Email: wkoch{at}dhm.mhn.de

Received November 19, 2007; Revised January 2, 2008; Accepted January 2, 2008

A role of thrombospondins in atherosclerosis and thrombosis was suggested by associations of single nucleotide polymorphisms in the genes coding for thrombospondin 1 (rs2228262; Asn700Ser), thrombospondin 2 (rs8089; 3' untranslated region), and thrombospondin 4 (rs1866389; Ala387Pro) with myocardial infarction. However, these findings were not consistently confirmed in replication studies. We determined the genotypes related to these polymorphisms in a large case-control sample of myocardial infarction and performed a meta-analysis of data obtained in the present sample and available from prior studies that included Europeans or Americans of European origin. In the population examined here, the carriers of the minor allele of the polymorphism in the thrombospondin 2 gene (GG and TG genotypes) had a mildly statistically significant higher risk of myocardial infarction than the homozygous carriers of the major allele (TT genotype) (adjusted OR 1.19; 95% CI, 1.02 to 1.39). In similar comparisons, no associations of the polymorphisms in the thrombospondin 1 (adjusted OR 1.12; 95% CI, 0.93 to 1.35) and thrombospondin 4 (adjusted OR 0.99; 95% CI, 0.85 to 1.16) genes with myocardial infarction were observed. The meta-analysis included 6388 (thrombospondin 1), 4930 (thrombospondin 2), and 6978 (thrombospondin 4) MI cases. None of the polymorphisms was found to be linked with the risk of myocardial infarction. Thus, despite associations in certain individual studies, the synthesis of available evidence did not suggest that the thrombospondin polymorphisms included in this study were associated with myocardial infarction.


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