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Human Molecular Genetics Advance Access published online on January 8, 2008
Human Molecular Genetics, doi:10.1093/hmg/ddn006
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cis- and Trans- Loci Influence Expression of the Schizophrenia Susceptibility Gene DTNBP1

Nicholas J. Bray1,3, Peter A. Holmans1,2, Marianne B. van den Bree1, Lesley Jones1, Lyn A. Elliston1, Gareth Hughes1, Alexander L. Richards1,2, Nigel M. Williams1, Nick Craddock1, Michael J. Owen1 and Michael C. O'Donovan1,

1 Department of Psychological Medicine and Cardiff University, Heath Park, Cardiff, CF14 4XN, UK 2 Biostatistics Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK 3 Centre for the Cellular Basis of Behaviour, Department of Neuroscience, Institute of Psychiatry, King's College London, SE5 9NU, UK

Correspondence should be addressed to: Michael O'Donovan, Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. Fax: +44-(0) 2920747839 Telephone: +44-(0) 2920743242 E-mail address: odonovanmc{at}cardiff.ac.uk

Received September 25, 2007; Revised January 7, 2008; Accepted January 7, 2008

Susceptibility to complex disease appears to be partly mediated by heritable differences in gene expression. Where cis-acting effects on a gene's expression influence disease susceptibility, other genes containing polymorphism with a trans-acting effect on expression of that gene may also be expected to modulate risk. Use of the expression of an identified disease gene as an endophenotype for quantitative linkage analysis may therefore provide a powerful method for mapping loci that modulate disease susceptibility. We performed genome-wide linkage analysis on expression of dystrobrevin binding protein 1 (DTNBP1), a well-supported susceptibility gene for schizophrenia, in large CEPH pedigrees. We observed genome-wide significant evidence for linkage at the DTNBP1 locus on chromosome 6p22, and demonstrated that this reflects variable cis-acting effects on DTNBP1 expression. In addition, we observed genome-wide suggestive evidence for linkage of DTNBP1 expression to chromosome 8p, suggesting a locus that exerts a trans-acting effect on DTNBP1 expression. The region of linkage to DTNBP1 expression on chromosome 8 is contiguous with linkage findings based upon the clinical schizophrenia phenotype, and contains another well-supported schizophrenia susceptibility gene, neuregulin-1 (NRG1). Our data provide complementary evidence for chromosome 8p as a susceptibility locus for schizophrenia, and suggest that genetic variation within this region may influence risk, at least in part, through effects on DTNBP1 expression.


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