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Human Molecular Genetics Advance Access published online on June 25, 2008
Human Molecular Genetics, doi:10.1093/hmg/ddn183
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease

Julien Chapuis1, Frédéric Moisan2,3, Georges Mellick4, Alexis Elbaz2,3, Florence Pasquier5, Didier Hannequin6, Corinne Lendon7, Dominique Campion6, Philippe Amouyel1 and Jean-Charles Lambert1,*

1 Inserm, U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France 2 Inserm, U708, Hôpital de la Salpêtrière, Paris, France 3 Université Pierre et Marie Curie-Paris6, Paris, France 4 Eskitis Institue for Cell and Molecular Therapies, Griffith University, Queensland, Australia 5 EA2391, department of Neurology, Memory Clinic, University Hospital of Lille, France 6 Inserm, U614, Faculty of Medicine, IFRMP, Rouen, France 7 Molecular Psychiatry Group, Queensland Institute of Medical Research, Brisbane, Australia

* Address correspondence to: Jean-Charles Lambert unité INSERM 744, Institut Pasteur de Lille BP 245,1, rue du professeur Calmette 59019 Lille cédex Tel: 33 (0)3 20 87 73 91 Fax: 33 (0)3 20 87 78 94 e-mail: jean-charles.lambert{at}pasteur-lille.fr

Received May 26, 2008; Revised June 22, 2008; Accepted June 22, 2008

Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD case-control studies (N=3,176) and two independent PD cases-controls studies (N=1,855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.


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