Cover: Analysis of the classical mouse mutant shaker-with-syndactylism using a positional candidate approach has revealed that loss-of-function mutations in the gene encoding the extracellular matrix protein fibrillin-2 lead to fusion of the digits. Background: a hind-paw of a wild-type mouse showing five distinct digits. Insets: alcian blue and alizarin red-stained hind-paw skeletal preparations showing the separated digits of a wild-type mouse (left) compared with the fusion of the digits that is typical of syfp/syfp mice (right). See Report by Chaudhry et al. in this issue, pp. 835-843..
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