Cover: Severely abnormal bone architecture in a trans iliac bone biopsy, from a child with idiopathic hyperphosphatasia (Goldner's trichrome stain, x 450 magnification). The normal network structure of trabecular bone is replaced with parallel trabecular plates with almost no cross-linking. A study investigating the genetic cause of this disorder has revealed an inactivating mutation in the gene encoding osteoprotegerin, a major regulator of bone turnover. See Article by Cundy et al., in this issue, pp.2119-2127.
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