Cover: The mitochondrial DNA (mtDNA)-encoded subunit I of cytochrome-c oxidase is uniformly expressed in mitochondria of exponentially growing, deoxyguanosine kinase (dGK) deficient fibroblasts, but mtDNA synthesis occurs mainly during the Sphase. Main panel and middle inset: Mitotracker-labelling of mitochondria (red) and immunostaining of subunit I (green) in control (main panel) and dGK deficient (middle inset) cells. Top and bottom insets: immunostaining of incorporated bromodeoxyuridine (green) in control (top inset) and dGK deficient (bottom inset) cells. Nuclei were counterstained with DAPI (blue). See Article by Taanman et al., in this issue, pp. 1839-1845.
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