Cover: Computer molecular modelling of wild-type and mutant IMPDH1 proteins. The model of IMPDH1 mutant product (pink)
exhibits significant predicted structural perturbation in the region of an introduced Arg224Pro point mutation when compared to
the model of wild-type protein (blue). The Arg to Pro mutation is highlighted in green. Background: light micrograph of a retinal
section from a 6-month-old Impdh1–/– mouse, which displays no structural degeneration of the retina. See Article by Aherne et al., in this issue, pp.641–650.
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