Cover: Analysis of PIP2 and F-actin in Lowe syndrome. Detection of PIP2 (green, antibody staining), F-actin (red, phalloidin staining) and DNA (blue, Dapi staining) in normal human dermal fibroblast stimulated by Platelet-Derived Growth Factor. PIP2 is not detected in ruffles (membranous actin-riched structures) of normal fibroblasts as shown here, while it accumulates in fibroblasts from Lowe syndrome patients. See Article by Faucherre et al., in this issue, pp. 1441–1448.
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