Cover: Coproporphyrinogen III oxidase, a unique enzyme involved in two tissue-specific human pathologies: only patients with mutation in amino acids D400-K404 in the helix highlighted in yellow (that moves to enclose the active site cavity) will develop erythropoietic harderoporphyria, whereas all other mutations lead to hepatic hereditary coproporphyria. See article by Schmitt et al., pages 3089-3098, this issue.
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