Cover: Aggregated polyglutamine proteins in the Drosophila eye from expression of a UAS controlled (CAA)94 repeat construct driven by GMR-GAL4. Horizontal cryosections are stained with Hoechst (blue) to show DNA and Myc antibody (green), which recognizes the Myc epitope tag on the C terminus of the polyglutamine protein. Short polyglutamine proteins encoded by (CAG)30 or (CAA)20 show a diffuse distribution. Polyglutamine proteins above the pathogenic threshold form tight aggregates, whether the polyglutamine is encoded by (CAG)99 or by (CAA)94. See Article by McLeod et al., in this issue, pp. 1041-1048.
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