Cover: Defects in cytoplasmic dynein and dynactin affect multiple pathways in the neuron. Analysis of multiple mouse models with disruptions in dynein or dynactin has shown evidence for defects in multiple cellular functions, including: impaired retrograde transport, decreased axonal caliber, destabilization of the neuromuscular junction, protein aggregation, and upregulation of degradative organelles; muscle atrophy has been observed in some models. Experimental data from multiple mouse models are summarized. Factors shown in green have been experimentally observed, whereas models experimentally shown to lack a particular feature are shown in red. See E.S. Chevalier-Larsen et al., pp. 1946-1955.
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