Cover: The cover figure shows cultures of human neural crest cells (nuclei, blue) co-expressing neural cell adhesion molecule (green) and alpha-smooth muscle actin (red). This cell population, which can be isolated from the three- to four-week embryo, gives rise to a wide but limited complement of cell types and tissues in vivo, yet has a transcriptional signature highly evocative of embryonic stem cells. See S. Thomas et al., pp. 3411-3425.
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