Cover: The cover figure shows solution structure of ZIC3 zinc finger domain. ZIC3 is the causal gene for X-linked heterotaxy (HTX1), which is a left-right axis disturbance of the internal organs. Some of the disease-associated missense mutations in the ZIC3 zinc finger motif 1 (ZF1) impair its nuclear localization. ZF1 and ZF2 are folded into a single structural unit (ZF1-2), which is connected by evolutionary-conserved tryptophan residues. The nuclear localization signal is interspersed in ZF2 and ZF3, and is required for the binding to nuclear transport receptors. Magenta balls are zinc atoms. See M. Hatayama et al., pp. 3459-3473.
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