Cover: The cover figure shows co-expression of the polymorphic human HAP1 (M441) with mutant huntingtin in cultured rat brain cortical neurons showing the co-localization of M441 with huntingtin aggregates. M441 is found to be a genetic modifier that delays the age onset of Huntington disease and has protection against huntingtin toxicity in cultured neurons, see Metzger et al., pp. 1137-1146.
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