Cover: The cover image shows during postnatal development, each climbing fiber (CF) first contacts several Purkinje cells (PCs) at their proximal compartment. Later on at about P10, terminal arbors of CFs retract and a single CF remains targeted to perisomatic spines on a single PC. The terminal arbors are subsequently displaced upward to intermediate and apical PC dendrites. This highly dynamic process of CF axon guidance is severely disturbed in the ether lipid-deficient mouse cerebellum in which CF synapses most frequently stay in proximal PC territories. PCs are visualized by anti-calbindin (red) and CF synapses by anti-vesicular glutamate transporter 2 (green) antibodies in cerebellar folium VI of 1-year-old animals. See A. Teigler et al., pp. 1897-1908.
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