Cover: The cover image shows zebrafish embryos were injected with mRNA encoding the C-terminal peptide of DUX4, a double homeobox gene located within the D4Z4 macrosatellite repeat units that are associated with fascioscapulohumeral muscular dystrophy (FSHD). This peptide inhibits myogenesis at a step between MyoD transcription and activation of MyoD targets as indicated by normal expression of MyoD but reduced expression of myogenin and myosin light chain mRNAs. The third row, left and center panels, shows in situ hybridization for MyoD and myogenin, respectively. Transcripts encoding the DUX-4 C-terminus are one of several newly identified forms of processed DUX4 RNA that are proposed candidates for the pathophysiology of FSHD. See L. Snider et al., pp. 2414-2430.
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