Cover: The cover highlights the unique genome organization mediated by complementary sites of nuclear scaffold and nuclear matrix attachment as revealed by array-CGH. Differential isolation of HeLa S3 nuclear matrices by 2 M NaCl and nuclear scaffolds by 25 mM LIS and analysis by array-CGH reveals distinct global profiles of scaffold/matrix attachment. Signal ratios for both loop:scaffold and loop:matrix comparative array hybridizations are displayed. Loop enrichment is shown in green and scaffold/matrix enriched regions are blue. Genes, shown in orange, are represented as density per megabase. Nuclear matrix attachment sites are concentrated in gene poor regions suggesting a global role in functional genome organization. See A. K. Linnemann et al., pp. 645-654.
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