Cover: Background: a section from an eye of Drosophila expressing a pathogenic human Huntingtin protein and human Hsp70 protein. Whereas the eye is severely degenerate on expression of the pathogenic Huntingtin protein, on co-expression of the molecular chaperone Hsp70 the detailed structure of the photoreceptor rhabdomeres is restored. Insets: comparison of a fly expressing a pathogenic human Machado–Joseph disease (MJD) protein in the eye with severe degeneration (left), and a fly co-expressing the pathogenic MJD protein with human Hsp70 in the eye, showing an external structure restored to normal. Molecular mechanisms by which chaperones achieve this suppression of toxicity include modulating protein solubility. See Article by Chan et al. in this issue, pp. 2811-2820.
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